Reid Laboratory | Clinical
Team | Vaughan Group | Pathology Group | Past Team Members |
| Reid Laboratory - Fred Hutchinson Cancer Research Center, Seattle, WA |
|
Brian J Reid M.D., Ph.D. is the Head of the Seattle Barrett's Esophagus Program. As an undergraduate and graduate student in Genetics, he discovered yeast cell cycle mutations and participated in developing the first genetic model of eukaryotic cell division. After graduate school, he entered medical school to study neoplastic evolution with the goal of improving care for patients who are at risk for or have cancer. He became a gastroenterologist and he has been investigating Barrett's esophagus since 1983. The goal of Dr. Reid's work on Barrett's esophagus is to understand the mechanisms by which environmental exposures (i.e. chronic reflux ; aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that leading to the development of esophageal adenocarcinoma in patients with Barrett's esophagus. This understanding can then be used to develop interventions to prevent progression to cancer or to detect the cancers and premalignant abnormalities when they are early and curable. Xiaohong Li is a Biostatistician whose expert knowledge is instrumental in turning experimental data into meaningful results. Carlo Maley Ph. D. is a Co-leader with Xiaohong Li of the Biostatistics and Evolutionary Analysis core resource. He applies evolutionary theory to the genetic data from Barrett's esophagus biopsies to discover the evolutionary dynamics of Barrett's cells during progression to cancer. In addition, he develops computational simulations of these dynamics so as to explore the implications of our theories of the progression of cancer. Carlo joined the team in 2000 and is now an assistant professor at the Wistar Institute in Philadelphia. Information on Carlo's work can be found here. Jessica Arnaudo is a technician on the molecular team currently generating and analyzing high throughput LOH assays using STRs and SNPs Valerie Cerera is a lab technician in the research laboratory. She is responsible for preparing esophageal biopsies for Ki67/DNA content cell sorting and assisting during research endoscopies. David Cowan is the lab's computer specialist, focusing on data acquisition and management, networking, web site development, systems maintenance, and data analysis. His current projects include researching methods of automating data collection, entry and retrieval (bioinformatics). He joined the Barrett's Esophagus Program in 1992. Patricia Galipeau has been studying genetic alterations in Barrett's esophagus since 1991. She has developed high-throughput techniques to asses genetic abnormalities and performs assays and analyses results of genetic lesions in a cohort of over 325 Barrett's patients. Using techniques of sequencing, automated fluorescent-based micro-satellite loss of heterozygosity analysis, DNA methylation, and array-based SNP analyses, she and the molecular team are evaluating mutation, LOH, and methylation of the p53 and p16 tumor suppressor genes as potential biomarkers to stratify patients at the highest risk of progressing to esophageal adenocarcinoma. In addition, Patricia is specializing in working with David Cowan and other software developers and database specialists to streamline data analysis, presentation, and storage of molecular data in large, human studies. Amber Karnofski is the Program Administrator and joined the Seattle Barrett's Esophagus Program in 2003. She primarily works with budget management and grant administration. She is responsible for most of the coordination aspects of the program. Heather Kissel is a molecular team lead developing SNPs for LOH using Pyrosequencing to identify genetic changes that occur in the progression of Barrett's esophagus to cancer. Thomas Paulson Ph. D. is a Staff Scientist who is investigating some of the causes and consequences of genetic instability during disease progression in patients with Barrett's esophagus. Tom joined the laboratory in 1997. Carissa (Rissa) Sanchez is the Project Manager for the Seattle Barrett's Esophagus Program and has worked with Dr. Reid since 1985. She introduced leadership and management practices to the laboratory learned from the Mastering Professional Management (MPM) program with Bob Dunham. She manages external research partnerships with the University of Washington, University of Arizona, Harvard Medical Center, and Brandeis University, amongst others. In the laboratory, she developed the Ki67/DNA content cell sorting protocol that has been used since the early 90s to purify Barrett's epithelial cells for molecular assays. Together with Peter Rabinovitch, she leads the flow cytometry team that assesses the flow cytometric measurement of aneuploidy and tetraploidy. Martin Suchorolski is a Graduate Student interested in neoplastic cell competition and modeling phenotypic changes in clonal populations in their progression to cancer. Martin joined the lab in summer 2005. |